Club EvMed: Ongoing evolution of SARS-CoV-2: an evolutionary medicine challenge for research and teaching - Shared screen with speaker view
Meredith Spence Beaulieu, Ph.D.
To raise hand, click “Participants” at the bottom and then you should see “Raise Hand” in the panel at the right.
Frank Rühli
Hi to everyone - just enjoying a nice sunset in Zurich…
Meredith Spence Beaulieu, Ph.D.
Glad you could join us!
Dan Eisenberg
not seeing slides
Dan Eisenberg
nevermind I see it
Joseph Graves Jr
I have been doing interviews from an EvMed perspective for Roland Martin Online. Roland Martin is a former CNN correspondent and his show is primarily viewed by persons of African descent.
Joseph Graves Jr
BTW, early in March on that show I predicted that we would see glaring disparities in incidence and death in African American and underserved minorities.
Frank Rühli
One of the major contributions our community can do - according to my personal view - is to challenge not-evidence based medical concepts , sort of “out-of-the-box-thinking”
Lily Hao
Trevor Bedford once mentioned 12 mutations. How is their data compared to yours?
Joseph Graves Jr
With those numbers are you separating NSyn and Syn mutations? So is 20 total mutations or 20 Nsyn mutations?
Adam Hunt
People ask about flu evolution and coronavirus evolution: will we expect coronavirus to come around every year, will we have an annual vaccine? if not, why is coronavirus different? A lot of public concern about viral evolution - and a good opportunity to prove the necessity of evo bio for understanding this!
Frank Rühli
Do you think that some of the global measures ( like quarantine, slowing down the spread etc) eventually have a functional mutational impact?
Dr Charles Nunn, Ph.D.
One Health perspectives are relevant to understanding the origins of SARS-CoV-2. How do you feel about One Health’s relation to evolutionary medicine, and how core concepts in ev med can contribute to One Health approaches?
Randolph Nesse
After years of reading fancy models of virulence evolution, it has been disappointing to see that they seem to be weak now that we really need them. Can they be useful? Can the current epidemic help assess them?
Randolph Nesse
Following up on Frank’s message…Can we predict how social distancing will influence virulence?
Frank Rühli
“Physical distancing” , not “social distancing”… ;)
Joseph Graves Jr
Concerning Randy’s question we would really need good data on the number of people that are infected and asymptomatic. The NIH antibody may help in this regard, but I also think it is under powered with collecting only 10,000 samples.
Joseph Graves Jr
Agreed that vaccine will require affinity to parts of the virus that are evolving slowly.
Kevin Boyd
Would you please discuss the phylogenetic relationship of CoV-2 with the avid virus associated with the so-called ‘Spanish’ flu; and why Spain is possibly not the true source of that 1919 pandemic?
Debayan Sinharoy
With healthcare workers in large cities getting exposed to patients infected from different sources, can we expect to see recombination of genetic material inside a person (a la HIV)? Also, is this clinically relevant? Hospitals as some sort of a marketplace of genetic diversity for the CoV?
Joseph Graves Jr
Agree with Jay, biggest issue I have teaching my Ev Med class at my HBCU is the student’s fear of mathematical reasoning.
Dr Charles Nunn, Ph.D.
For Randy’s question on virulence: the models are good but data are harder to come by and will take some time. E.g. we need to know how replication rate influences both transmission probability and death rate (virulence), which tradeoff in the eqn for R0. I think only HIV has the data necessary to test the tradeoff model, and supports it… at least for human disease. Anyone know of other solid tests of tradeoff model for a human ID?
Joseph Graves Jr
To Charlie’s point for COVID another aspect of its tradeoff relations will be persistence on environmental surfaces - not an issue for HIV.
Michael Reiskind
are any of the sequences linked with clinical information?
Joseph Graves Jr
To Michael’s point we absolutely need to link clinical death/illness to specific genetic variants.
Debayan Sinharoy
Re. the virulence/transmissibility trade-off: maybe some research was done on some herpesvirus and squirrel/spider monkeys. (Not a virologist) Will see if I can find the papers.
Duane Stilwell
How is it that an old TB vaccine confers some benefits during this Covid-19 pandemic? I’m thinking that might be interesting…
Michael Reiskind
I read that part of the clinical description in China included diarrhea. I haven’t heard this recently. last weeks speakers mentioned the enteric nature of coronaviruses in bats. could ancestral strains have shifted away from a fecal-oral transmission?
Michael Reiskind
lots of prior research at NCSU on poultry coronaviruses
Debayan Sinharoy
A lot of papers are now suspecting antibody-dependent enhancement influencing the severity of symptoms (a second hit with a different strain causing more harm). Maybe the genomic association studies for symptoms might not yield a lot of meaningful info…
Fred Fox
In addtion to BCG vaccination, influenz vaccination seems to have benefit by increasing the innate immunological response and that intradermal vaccination route may augment this even more.
Joseph Graves Jr
Concerning diarrhea in China, there are genetic differences between East Asians, Europeans, and Africans; as well as differences in intestinal microbiomes, so it would be hard to tell if the differences in symptoms result from changes in the virus or changes in who it is infecting.
Debayan Sinharoy
Saw another preprint today that links MMR vaccine. Shoddier then the BCG studies IMO.
Mark Friedman
One of the medicines that has shown some efficacy against Covid-19, when used with other medications, in reducing symptoms, duration and morbidity has been a Cuban developed interferon alpha2B. They have used this in Cuba for some time against HIV, meningitis, MERS, prior SARS outbreaks. China has made millions of doses and distributed them. Efforts are underway to get the clinical trial results from Cuba, China and now Italy. A national campaign is underway across the US to get FDA and OFAC approval for import---breaking the blockade against Cuba. Can you explain, to this HS physio-anatomy teacher, how interferon works ...or perhaps someone else on the call can.
Michael Reiskind
very interesting Vaughn! great job and good to see you!
Vaughn Cooper
Thanks everyone. I’m at vaughn dot cooper at pitt dot edu
Vaughn Cooper
re: education, please visit evolvingstem dot org
Alejandro Berrio Escobar
Thank you Vaughn and TriCEM! :)
Annie Wang
Thank you Vaughn!
Prarthana M S
Thank you.