Logo

Club EvMed: Understanding evolutionary mismatch at the genomic level - Shared screen with speaker view
Charles Nunn
19:59
https://academic.oup.com/emph/article/2017/1/201/4911520
Joseph Graves Jr
29:09
How many passages of the cell lines occurred before they were exposed to the treatments?
Charles Nunn
40:25
Please feel free to post questions and perspectives in the chat! We will open up for discussion at the end of Amanda’s talk.
Gillian Bentley
42:06
I noticed that the figure that you showed in relation to the context-dependent eQTLs and associated diseases had mostly?/many auto-immune diseases and wondered what the significance of this might be
Bernie Crespi
43:07
Why do you think that so many of the context dependent eQTLS were associated with *autoimmune* diseases? Because you used B cells? Could the higher positive selection signal on context-dependent eQTLs involved in immunity be a function of infectious disease-related selection, given that autoimmune loci are related to infectious disease risks? How does this fit in with mismatch and, say, obesity? Inflammation effects?
Joseph Graves Jr
49:03
I am interested that you decided to use life span associated genes for this study. No one really knows how long flies live in nature. I think to would have been better to do this study on fecundity which would be more closely related to fitness in nature than life span.
Meredith Spence Beaulieu, PhD (she/her/hers)
53:46
Feel free to virtually raise your hand with any questions or perspectives!
Meredith Spence Beaulieu, PhD (she/her/hers)
54:39
To raise hand, click “Reactions” at the bottom of your screen, then “Raise Hand”
Gillian Bentley
57:51
I also wondered why you chose as the "challenges" to the cell lines, environmental pollutants, but not in your Drosophila model? Isn't that a mismatch between the cell line work and the model organism?
Meredith Spence Beaulieu, PhD (she/her/hers)
01:05:31
We have time for 1-2 more questions or perspectives! Feel free to post in the chat or raise your hand.
Ronald Willis
01:07:05
What evidence would it take to prove the mismatch hypothesis? are there any “stubborn facts” that undermine the hypothesis? Or are we stuck with fuzzy science?