Club EvMed: Understanding evolutionary mismatch at the genomic level - Shared screen with speaker view
Charles Nunn
Joseph Graves Jr
How many passages of the cell lines occurred before they were exposed to the treatments?
Charles Nunn
Please feel free to post questions and perspectives in the chat! We will open up for discussion at the end of Amanda’s talk.
Gillian Bentley
I noticed that the figure that you showed in relation to the context-dependent eQTLs and associated diseases had mostly?/many auto-immune diseases and wondered what the significance of this might be
Bernie Crespi
Why do you think that so many of the context dependent eQTLS were associated with *autoimmune* diseases? Because you used B cells? Could the higher positive selection signal on context-dependent eQTLs involved in immunity be a function of infectious disease-related selection, given that autoimmune loci are related to infectious disease risks? How does this fit in with mismatch and, say, obesity? Inflammation effects?
Joseph Graves Jr
I am interested that you decided to use life span associated genes for this study. No one really knows how long flies live in nature. I think to would have been better to do this study on fecundity which would be more closely related to fitness in nature than life span.
Meredith Spence Beaulieu, PhD (she/her/hers)
Feel free to virtually raise your hand with any questions or perspectives!
Meredith Spence Beaulieu, PhD (she/her/hers)
To raise hand, click “Reactions” at the bottom of your screen, then “Raise Hand”
Gillian Bentley
I also wondered why you chose as the "challenges" to the cell lines, environmental pollutants, but not in your Drosophila model? Isn't that a mismatch between the cell line work and the model organism?
Meredith Spence Beaulieu, PhD (she/her/hers)
We have time for 1-2 more questions or perspectives! Feel free to post in the chat or raise your hand.
Ronald Willis
What evidence would it take to prove the mismatch hypothesis? are there any “stubborn facts” that undermine the hypothesis? Or are we stuck with fuzzy science?